After the drug-fuelled high comes the crash. Cocaine-withdrawal causes a protracted biochemical abstinence-syndrome marked by craving and anhedonia. Neuronal release of dopamine declines. So does the number of mesolimbic dopamine transporters. The spontaneous firing of dopamine cells decreases. Chronic cocaine dependence may cause long-lasting functional deficits in the frontal cortex as well.
The hedonic treadmill punishes naive attempts to get high.
The Hedonistic Imperative
Critique of Huxley's Brave New World
When Is It Best To Take Crack Cocaine?
The Good Drug Guide
The Responsible Parent's Guide To Healthy Mood Boosters For All The Family